November 24, 2014

If Dementia Is Coming My Way, Is It HS-AGING?

My 85-year-old body houses a variety of conditions all under one roof -- prostate cancer (lingering after a prostatectomy 20 years ago), Parkinson’s disease, neurogenic orthostatic hypotension, occasional trouble with constipation, insomnia, depression.... I’ll stop there for now.

Add to those problems the interaction of many drugs and supplements I’ve been taking for years. While the pills I pop surely address the particular issues they’re designed to help, the combination of all of them creates a complex chemical brew in my bloodstream and brain.

I've talked often about my fears of Alzheimer's but now my concern is more specific -- Parkinson's disease dementia. My worries are well founded. Estimates are that 50 to 80 percent of us with Parkinson's end up getting this.  Three recent studies have identified traits that put those of us with Parkinson's at increaded risk for Parkinson's dementia. I have all three of those traits. And if that isn't enough, I'm seeing signs in my daily life that dementia is waiting to play a bigger role.

While Parkisnson's dementia is the best bet as the cause of any cognitive decline I'm experiencing, I uncovered a potential new explanation in a recent article  in  Alzheimer’s Weekly titled “85 with Dementia? Good Chance It's HS-AGING and Not Alzheimer's.”

They hit my age on the nose – 85 – in that headline, so I took a closer look.

The review is clearly laid out, so it’d be crazy for me to recap it. Here it is:

<> <> <> <> <> <> <>


3 recent dementia studies focus on HS-AGING. It's a type of dementia almost as common as Alzheimer's in the 85+ group. Yet few people have heard of it. Why? What makes it different? 

In those who live to a very advanced age (beyond the age of 85) HS-AGING (hippocampal sclerosis in the elderly) is almost as prevalent as Alzheimer's. Remarkably, HS-Aging appears to be a completely separate disease from Alzheimer's, although it is almost always diagnosed as Alzheimer's disease while people are alive.

Three recent papers authored by Dr. Peter Nelson and others at the University of Kentucky Sanders-Brown Center on Aging, explore the neuropathology behind this little-understood brain disease.

HS-AGING, much like Alzheimer's disease, causes symptoms of dementia, such as cognitive decline and impaired memory. Although Alzheimer's disease is probably the most recognized cause of dementia, HS-AGING also causes serious cognitive impairment in many older adults.

Overview of 3 New Studies on HS-AGING:

  1. The first paper, published in the Journal of Alzheimer's Disease, draws from a very large sample population and shows that presently, around 20% of all dementia cases are diagnosed as HS-AGING at autopsy, although almost none are given that diagnosis during life. That means that the presence of this disease is currently almost unknown by the health care providers who are seeing patients.
  2. A second study, "Arteriolosclerosis that affects multiple brain regions," appears in a recent issue of the journal Brain, and looks at small blood vessels in patients with HS-Aging and describes a specific change, called "arteriolosclerosis," which is present in patients with HS-Aging. This small blood vessel change may provide a new therapeutic target to alter the progression of the disease.
  3. Finally, the third paper, "Hippocampal sclerosis of aging, a prevalent and high morbidity brain disease," appears in Acta Neuropathologica and offers an overview of HS-AGING for patients and researchers. This paper reviews the relevant scientific literature and also presses home the point that HS-AGING is a very common disease that exerts a strongly adverse impact on public health.
It is important for physicians and scientists to understand the unique pathology of HS-AGING, and to be able to differentiate it from other diseases, as it is only by making an accurate diagnosis that clinicians can hope to treat people who present with signs of cognitive decline. These current studies represent a leap forward in the knowledge base about HS-AGING, and represent potential new paths to explore for diagnosis and treatment of this serious, but under-appreciated brain disease.

In people over 95, a type of dementia called HS-Ageing is about as common as Alzheimer's. Yet few people have heard of it. Why? What makes it different?

What is HS-Ageing?
HS-Ageing stands for “Hippocampal Sclerosis in Ageing People”.

Alzheimer’s and HS-Ageing are types of dementia. In people over 95, their prevalence is about equal.

HS-Ageing is Not Well Known. Everyone Has Heard of Alzheimer’s. Why?

There are hundreds of types of dementia. In people aged 65 to 95, 60% of dementia cases are Alzheimer’s. That is why Alzheimer’s is so well-known.

At age 95, the balance shifts and HS-Ageing becomes about as common as Alzheimer’s.

Few people have heard of HS-Ageing. The main reason is because it is often mis-diagnosed as Alzheimer's. Why?

When dementia is seen in the elderly, the default diagnosis is Alzheimer's. This is caused by many factors, among them:

  • Patients often do not want to go through extensive testing for a variety of reasons.
  • There is no simple test. The differences between dementias can be subtle. Therefore, distinguishing between dementias is often technically challenging.
  • Cost comes into play. For example, F18 dementia scans can run thousands of dollars. Therefore, many a diagnosis is made based on incomplete information.
With these realities, it is common for a diagnosis to default to the most common dementia, which is Alzheimer's.

As a result, people with dementias such as HS-Ageing often live out their lives thinking they have Alzheimer's.

How does HS-Ageing differ from Alzheimer’s?
Alzheimer’s and HS-Ageing both damage the hippocampus. It seems that HS-Ageing hits harder than Alzheimer’s, causing greater disturbances to memory.

HS-Ageing describes a brain under attack from a protein called TDP-43. It causes sclerosis, or the hardening of tissues. In the case of HS-Ageing, TDP-43 proteins harden brain tissue in the hippocampus (sometimes called the memory-processing center), causing the loss of a large number of crucial brain cells. It is called Hippocampal Sclerosis because the brain’s hippocampus is the focus of the attack.

Alzheimer’s, on the other hand, is an attack on the brain by plaques (made from beta-amyloid) and tangles (made of tau proteins). Researchers speculate that the plaques clump together and “choke” brain cells, while the tangles strangle them from within.

How does HS-Ageing differ from regular HS?
Regular Hippocampal Sclerosis (HS) occurs in younger people where brain tissue hardening is associated with epilepsy. HS-Ageing is a similar hardening, but it occurs in the elderly with different consequences. It is caused by a long life of physical wear-and-tear on the brain, similar to vascular dementia. As a matter of fact, once people hit 95, the combined occurrences of HS-Ageing PLUS vascular dementia actually outstrip Alzheimer’s.

Why does the type of dementia matter?
As explained above, the biochemistry of each dementia differs significantly. This implies different medications are required to fight the chemicals causing the dementia. A person’s response to medicines and supplements will be entirely different, depending on the disease.

Importantly, new F18 imaging techniques have recently been introduced that let doctors see if a person with dementia has the plaques associated with Alzheimer's. Using this technique helps doctors tell the difference between Alzheimer’s and HS-Ageing. This is particularly crucial in the world of clinical trials, where participants must closely match the experimental drugs they are testing.

CTE Research Leading to Rapid Improvements in HS-Ageing Treatments

When we talk about dementia in older athletes, it is usually the type of dementiacalled CTE (Chronic Traumatic Encephalopathy). Recent studies showed athletes in contact sports like football are 19 times more likely than average to develop dementia. As a result, there has been a huge burst of research on CTE treatment.

CTE treatment has a lot in common with HS-Ageing treatment. With the new attention both of these dementias are now receiving, there is good reason to hope for effective new treatments in the immediate future.

<> <> <> <> <> <> <>

Suppose that's my issue? One more reason why I'm looking forward to being checked out by two top neurologists in the coming week -- the head of the Parkinson's disease center at George Washington Hospital and the head of the Parkinson's Disease and Movement Disorders Center of  Maryland, which is affiliated with Johns Hopikins.

I'll still place my bet on Parkinson's dementia.

Stay tuned.



1 comment:

Anna said...

John,

Have you considered "integrative medicine"? In this video, it is suggested that a particular form of acupuncture can help PWPD reduce dependency on some medications.

http://thecuretocancersummit.com/video-4-dr-sunil-pai/

Anna

UA-20519487-1