- Free water in the substantia nigra is elevated in people with PD.
- What’s more, those water levels increase as the disease progresses.
- Free water levels could predict – yes, in advance – changes in bradykinesia (slowness of movement common in PD) and cognitive status in people with PD. The more the water had accumulated, the greater the likelihood that future movement would be slowed and cognition affected.
The Parkinson’s drugs available today help reduce symptoms. They don’t slow the progression of the disease, which is the major unmet medical need. We’ve provided a tool to test promising new therapies that could address progression.